Context : certain harmful molecules (called AGEs & ALEs) derived from sugars or lipids accumulate over time in our organism and cause the aging of the human body.
AGEs (Advanced Glycation Endproducts) are modifications of proteins induced by compounds resulting from the oxidative metabolism of carbohydrates strongly implicated in aging, especially in the skin, and in certain associated pathologies such as diabetes complications.
ALEs (Advanced Lipid Peroxidation Endproducts) are also modifications of proteins formed by reaction with compounds resulting from the degradation of polyunsaturated fatty acids, and are involved in the aggravation of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease.
Considering the very serious pathological consequences, the development of molecules inhibiting or attenuating the formation of AGEs and ALEs is of considerable interest. No effective molecule preventing the formation of AGEs AND ALEs has been developed so far.